LncRNA NKILA suppresses airway hyper reactivity via interfering the facilitation of MUC5AC and MUC5B mediated by GALNT2
نویسندگان
چکیده
منابع مشابه
Airway Mucus and Asthma: The Role of MUC5AC and MUC5B
Asthma is characterized by mucus abnormalities. Airway epithelial hyperplasia and metaplasia result in changes in stored and secreted mucin and the production of a pathologic mucus gel. Mucus transport is impaired, culminating in mucus plugging and airway obstruction-a major cause of morbidity in asthma. The polymeric mucins MUC5AC and MUC5B are integral components of airway mucus. MUC5AC and M...
متن کاملMuc5b and Muc5ac are the major oligomeric mucins in equine airway mucus.
Horses frequently suffer from respiratory diseases, which, irrespective of etiology, are often associated with airway mucus accumulation. Studies on human airways have shown that the key structural components of the mucus layer are oligomeric mucins, which can undergo changes of expression and properties in disease. However, there is little information on these gel-forming glycoproteins in hors...
متن کاملIdentification of MUC5B, MUC5AC and small amounts of MUC2 mucins in cystic fibrosis airway secretions.
To investigate the genetic identities of the mucins secreted in cystic fibrosis (CF) airways, sputum was collected from five individuals. Samples were separated into gel and sol phases by high-speed centrifugation and the gel phase was extracted in 6 M guanidinium chloride. The 'insoluble' residue remaining after extraction of the gel phase was brought into solution by reduction/alkylation. Den...
متن کاملEndotoxin contamination of ovalbumin suppresses murine immunologic responses and development of airway hyper-reactivity.
The reversible airway hyper-reactivity (AHR) of asthma is modeled by sensitizing and challenging mice with aerosolized ovalbumin. However, the C57BL/6 murine strain does not display the large increase in circulating IgG and IgE antibodies found in human atopy and asthma. We found that commercial ovalbumin was contaminated with lipopolysaccharide (LPS) in amounts sufficient to fully activate end...
متن کاملMUC5AC and MUC5B mucins increase in cystic fibrosis airway secretions during pulmonary exacerbation.
RATIONALE Cystic fibrosis (CF) is believed to be associated with mucus hypersecretion; thus, the principal airway gel-forming mucins, MUC5AC and MUC5B, are also expected to be increased relative to non-CF secretions. However, we have shown that these mucins are decreased during stable CF disease. OBJECTIVES In this study, we determine if these mucins increase during a pulmonary exacerbation o...
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ژورنال
عنوان ژورنال: BIOCELL
سال: 2021
ISSN: 1667-5746
DOI: 10.32604/biocell.2021.010454